Defining and Combating the Mechanisms of Triclosan

Initially it was thought that the mode of antibacterial action of triclosan was via a general disruptive effect on bacterial membranes () However it has now been shown that the mode of action of triclosan is via inhibition of enoyl-acyl carrier protein (ACP) reductase (FabI) in organisms such as Staphylococcus aureus and Escherichia coli that rely on this enzyme to perform the ultimate step

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The commonly used antimicrobial additive triclosan

Triclosan [5-chloro-2-(2 4-dichlorophenoxy)phenol TCS] is a broad-spectrum antimicrobial agent that has become one of the most common additives used in consumer products As a result TCS has significantly affected the environment and has been frequently detected in human body fluids Through a long-term feeding study we found that TCS enhances hepatocyte proliferation fibrogenesis and

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Title: A study of the mechanism of action of triclosan and

Conclusions were drawn that triclosan had a single primary target in bacteria and the previously reported effects of triclosan on membrane structure were secondary effects arising from specific inhibition of the fatty acid biosynthetic pathway In this study the mechanisms of action of both triclosan and PCMX were investigated against the hygiene indicators E coli NCTC 8196 and S aureus

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UNDER THE MICROSCOPE Triclosan – an update

UNDER THE MICROSCOPE Triclosan – an update S Saleh1 R N S Haddadin2 targeted modes of action (e g: triclosan) to generate cross-resistance towards other antimicrobial compounds They suggested that it is possible for the overuse of triclo-san to cause cross-resistance in antibiotics It is believed that this may be caused by the bacterial cells developing changes in the intracellular

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microbiology

Triclosan is a chemical often referred to as a biocide instead of an antibiotic However its mode of action seems to suggest that it is an antibiotic Triclosan binds to bacterial enoyl-acyl carrier protein reductase (ENR) enzyme which is encoded by the gene FabI This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide (NAD+)

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CiteSeerX — Citation Query Mechanism of Triclosan

Understanding the in vivo mechanism of action (MoA) of biologically active compounds is an elementary requirement for drug discovery and development Until recently in vivo MoA analysis was mostly limited to cases in which in-depth knowledge of the respective biological pathway was available With the advancement of genomics however new technologies with the potential to address this

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Triclosan (Mechanism of Bactericidal Action and Toxicity

Triclosan a widely used bactericide has been the object recently of increased attention by the media and scientists in relation to safety and usefulness This chapter deals with a unifying mechanism for antibacterial action and toxicity based on electron transfer (ET) reactive oxygen species (ROS) and oxidative stress (OS) The phenolic compound can be oxidatively converted to diols

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Triclosan

Triclosan is the antibacterial ingredient in Colgate Total and it provides the plaque and gingivitis benefits of the dentifrice Since it is an uncharged molecule triclosan itself has poor retention (substantivity) in the oral cavity (Figure 10) 50-52 Colgate Total is formulated with a special polymer (Gantrez ) which increases the substantivity of triclosan in the oral cavity

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Triclosan

Mechanism of action At high concentrations triclosan acts as a biocide with multiple cytoplasmic and membrane targets [28] However at the lower concentrations seen in commercial products triclosan appears bacteriostatic and it targets bacteria primarily by inhibiting fatty acid synthesis

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Sublethal concentrations of triclosan elicited oxidative

Triclosan (TCS) an antimicrobial agent has been a pollutant of increasing concern owing to its potential health risk on humans and aquatic animals The present study seeks to test the hypothesis that TCS could alter the oxidative stress-related parameters in the brain and liver as well as eliciting DNA damage in hepatocytes of adult zebrafish On the basis of the 96nbsp h LC50 (398 9nbsp

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Triclosan

Triclosan similar in its uses and mechanism of action to triclocarban is an antibacterial and antifungal agent found in consumer products including toothpaste soaps detergents toys and surgical cleaning treatments Its efficacy as an antimicrobial agent the risk of antimicrobial resistance and its possible role in disrupted hormonal development remain controversial

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1 What is the biocide triclosan?

Inhibition of key metabolic pathway and synthesis (Regos and Hitz 1974 McMurry et al 1998b) might be part of the lethal action mechanisms of triclosan Indeed triclosan was found to target specifically fatty acid synthesis with the inhibition of the enzyme enoyl reductase (enoyl-acyl carrier protein reductase FabI) (McMurry et al 1998a)

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About: Triclosan

Triclosan similar in its uses and mechanism of action to triclocarban is an antibacterial and antifungal agent found in consumer products including toothpaste soaps detergents toys and surgical cleaning treatments Its efficacy as an antimicrobial agent the risk of antimicrobial resistance and its possible role in disrupted hormonal development remain controversial Additional

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Triclosan: environmental exposure toxicity and

Triclosan: environmental exposure toxicity and mechanisms of action Dann Andrea B Hontela Alice 2011-05-01 00:00:00 ABSTRACT Triclosan (5‐chloro‐2‐(2 4‐dichlorophenoxy)phenol TCS) is a broad spectrum antibacterial agent used in personal care veterinary industrial and products TCS is commonly detected in aquatic

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Effects of Triclocarban Triclosan and Methyl Triclosan

Triclosan (TCS) and triclocarban (TCC) are widely used broad spectrum bactericides that are common pollutants of waterways and soils Methyl triclosan (mTCS) is the predominant bacterial TCS metabolite Previous studies have shown that TCS disrupts thyroid hormone (TH) action however the effects of mTCS or TCC are not known The present study uses the cultured frog tadpole tail fin biopsy (C

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10 Reasons You Should Know About Triclosan

Triclosan is an antibacterial and anti-fungal agent present in some consumer products including toothpaste soaps detergents toys clothes animal beds and surgical cleaning treatments It is similar in its uses and mechanism of action to triclo-carban So what is it really? Well it's a pesticide

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Triclosan: environmental exposure toxicity and

Triclosan: environmental exposure toxicity and mechanisms of action Dann AB(1) Hontela A Author information: (1)Department of Biological Sciences Alberta Water and Environmental Science Bldg 4401 University Dr W University of Lethbridge Lethbridge Alberta Canada Triclosan [5-chloro-2-(2 4-dichlorophenoxy)phenol TCS] is a broad spectrum antibacterial agent used in personal care

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Triclosan: environmental exposure toxicity and

Triclosan [5-chloro-2-(2 4-dichlorophenoxy)phenol TCS] is a broad spectrum antibacterial agent used in personal care veterinary industrial and products TCS is commonly detected in aquatic ecosystems as it is only partially removed during the wastewater treatment process Sorption biodegradation and photolytic degradation mitigate the availability of TCS to aquatic biota

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10 Reasons You Should Know About Triclosan

Triclosan is an antibacterial and anti-fungal agent present in some consumer products including toothpaste soaps detergents toys clothes animal beds and surgical cleaning treatments It is similar in its uses and mechanism of action to triclo-carban So what is it really? Well it's a pesticide

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Triclosan: a widely used biocide and its link to antibiotics

Mode of action Until a specic target was described in 1998 triclosan was thought to act as a non-specic biocide by aecting membrane structure and function [6 7] Isolated cell walls and whole cells of Escherichia coli Staphylococcus aureus and Pseudomonas aeruginosa were shown to absorb triclo-san by diusion and it was suggested that the degree of absorption was proportionate to the

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Triclocarban

Triclocarban (sometimes abbreviated as TCC) is an antibacterial chemical once common in but now phased out of personal care products like soaps and lotions It was originally developed for the medical field Although the mode of action is unknown TCC can be effective in fighting infections by targeting the growth of bacteria such as Staphylococcus aureus

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